Association of Platelet-Monocyte Ratio with Dyslipidemia in Saudi Arabia: A Large, Population-Based Study

Background: Abnormal lipid metabolism predisposes to cardiovascular disease. However, dyslipidemia is often asymptomatic leading its underdiagnosis. Therefore, it of utmost importance identify biomarkers that reflect an abnormal profile and trigger the specific investigation metabolism. The platelet–monocyte ratio (PMR) a severely understudied index whose association with disturbed markers remains unknown. Methods: A cross-sectional study between PMR comprehensive including total cholesterol (TC), low-density lipoprotein (LDL), high-density (HDL), triglycerides (TG), TC/HDL, LDL/HDL, TG/HDL in 14,269 Saudi subjects was designed. Prevalence, risk measures, association, diagnostic performance (i.e., area under curve (AUC)) were evaluated. Results: Median significantly elevated high TC (p < 0.01), TG, TG/HDL, LDL reduced those low HDL (all p 0.0001) compared normal subjects. increase abolished when only males considered. Except for LDL, all other more prevalent lower (higher HDL) than certain cutoff each parameter. Moreover, odds having readings above or below selected cutoffs are higher abnormalities. also weakly but differentially correlated forms 0.0001). Notably, highest accuracy observed (AUC = 0.608, 0.596, Conclusions: novel, inexpensive, readily available associated dyslipidemia, suggesting potential use related disorders.